Investigate Human Microbiome Diversity and Function with Advanced Metagenomics
Leverage Cosmos-Hub for comprehensive human microbiome analysis across multiple body sites
Why Human Microbiome Research Matters
The human microbiome plays a crucial role in health and disease. From gut health to skin conditions, understanding microbial composition and function provides valuable insights into diagnostics, therapeutics, and personalized medicine. Cosmos-Hub enables researchers to explore human microbiomes at high resolution, empowering studies in areas such as digestive health, metabolic disorders, infections, and immune modulation.
Cosmos-Hub’s advanced tools provide crucial insights into the microbiomes of various body sites, essential for:
Investigating gut microbial influences on digestion, inflammation, and metabolism.
Studying skin microbiome interactions with dermatological health and immunity.
Analyzing oral microbiota for links to dental and systemic health.
Exploring vaginal microbiome associations with reproductive health and infections.
Characterizing tumor microbiomes for potential oncobiome interactions.
Evaluating the small intestinal microbiome through Nimble capsule sampling.
Sample Types in Human Microbiome Research
Cosmos-Hub has been used to analyze every human sample type you can think of over the years but here are some of the more popular ones. Don't see your sample type here? Contact us and we can demo some relevant datasets.
Allow investigation into microbial contributions to cancer development and therapy responses.
How Cosmos-Hub Helps
Shotgun Metagenomics and CHAMP Profiling
Our shotgun metagenomics services provide high-resolution insights into the human microbiome. Using our proprietary CHAMP profiler—the most sensitive and accurate human microbiome profiler available—we offer detailed taxonomic and functional profiling to help researchers explore how microbial communities influence human health.
Functional Profiling
Our functional profiling for stool samples leverages curated gut-metabolic modules to explore microbial contributions to key processes, including:
Short-chain fatty acid (SCFA) production for gut health.
CAZyme analysis for fiber degradation and dietary metabolism.
Bile acid metabolism for gut-liver interactions.
KEGG module integration, offering a comprehensive overview of metabolic pathways affecting digestion and metabolic health.
MetaCyc Database: A comprehensive metabolic pathway database that provides insights into microbial enzymatic functions and biochemical reactions.
Enzyme Commission (EC) Classification: Organizes enzymes based on their catalytic activity, aiding in the identification of microbial enzymatic roles.
Gene Ontology (GO): A framework for categorizing microbial genes based on their associated biological processes, molecular functions, and cellular components.
Pfam Database: A collection of protein families and domains that helps characterize microbial proteins and their functional roles in metabolism and gene expression.
Real-World Impact of Human Microbiome Analysis with Cosmos-Hub
Cosmos-Hub has been instrumental in numerous studies exploring human microbiomes. Here are some key publications highlighting its impact:
Antibiotic use in the past 8 years and gut microbiota composition. Baldanzi, G., Larsson, A., Sayols-Baixeras, S., Dekkers, K. F., Hammar, U., Nguyen, D., Graells, T., Ahmad, S., Volpiano, C. G., Meric, G., Järhult, J. D., Tängdén, T., Ludvigsson, J. F., Lind, L., Sundström, J., Michaëlsson, K., Ärnlöv, J., Kennedy, B., Orho-Melander, M., & Fall, T. (2024). medRxiv. https://doi.org/10.1101/2024.10.14.24315441
Effect of topical microencapsulated benzoyl peroxide on the skin microbiome in rosacea: A randomized, double-blind, crossover, vehicle-controlled clinical trial. Nong, Y., Sugarman, J., York, J. P., Levy-Hacham, O., Nadora, D., Mizrahi, R., Galati, A., Gallo, R. L., & Sivamani, R. K. (2024). Journal of Clinical and Aesthetic Dermatology, 17(8), 19-26.
